Drug allergy testing (specialist)

Drug allergy testing requires a specialist testing facility, and this new service is being undertaken by RefLab ApS, Copenhagen, Denmark (ISO 17025 accredited).

The drug-induced basophil activation test (BaHRT) is based on allerge- induced histamine release from patients' own cells. Each drug is tested in titration and in 12 concentrations, with results expressed as a threshold value (mg/mL or μg/mL or ng/mL) of the drug, indicating the level of sensitivity. A healthy control is always included as reference for non-specific release.

With positive detection at 70% [1], a POSITIVE test result will confirm sensitization. A negative result does not exclude possible drug allergy. A drug allergy challenge test in a specialised allergy centre is indicated for EACH negative drug allergy results to achieve a definitive diagnosis.

Please contact TDL’s Referrals Department for drug availability – in most cases it will be possible to carry out testing, as drug availability is increasing and specialty drugs can be tested upon request.

The drug itself can be sent with the sample to RefLab in Denmark.

Samples must be taken on Mondays, Tuesdays and Wednesday and received by noon in the laboratory for same day referral to Denmark.

For more information, please contact the laboratory. 


[1] Pineda F, et al. Role of Histamine Release Test for the Evaluation of Patients with Immediate Hypersensitivity Reactions to Clavulanic Acid. Int Arch Allergy Immunol 2015; 168:233-240.


Test name
Penicillin Antibiotic Panel (BaHRT)
Perioperative Anaphylaxis Panel (BaHRT)
Single drug allergy test – please specify drug