Coeliac/Gluten Profile 2

Profile details

Endomysial IgA
Gliadin deamidated lgG
Total IgA*
Tissue Transglutaminase (IgA)
HLA DQ2/DQ8

Code

GSA2

Sample Reqs

AB

Turnaround

10 days

Special instructions

*To reduce the risk of missing IgA deficient patients, a Total IgA will be run for all low Tissue Transglutaminase IgA results. If IgA deficiency is identified, a reflex deaminated Gliadin IgG will be carried out to determine whether the patient is likely to have coeliac disease. Coeliac pathway:

  1. Initial TTG IgA samples are received and tested
  2. If TTG IgA is LOW <0.2 U/ml reflex testing for Total IgA will be undertaken
  3. If Total IgA is LOW <0.1 g/L then reflex testing for Gliadin IgG test will be undertaken
  4. If TTG IgA is HIGH (>/= 10 U/ml then reflex testing for Endomesial IgA will be undertaken as a confirmatory test.



Sample type guide

A

Lavender Vacutainer, EDTA anticoagulant, 4ml/10ml (10ml EDTA tubes are used for specific PCR assays)

B

Gold Vacutainer, SST/Gel anticoagulant, 5ml

See the Sample Requirements page for an explanation of all the sample requirements.

See the Special Instructions Legend page for a full list of special instructions.

Last-updated: 24/12/2021

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